Bioss Inc.'s BMI1 (2T6) Monoclonal Antibody is a Mouse monoclonal antibody. The BMI1 (2T6) Monoclonal Antibody was generated using BMI1, and COMMD3-BMI1 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunofluorescence, and Western Blot.
Description
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2